2012
Cardiac Repair Models
Smart et al. · Nature
Investigated actin-regulatory peptides including thymosin β-4 fragments in cardiac progenitor mobilization.
Best Seller
Lot CB26-04-002MFG 04/2026
About TB-500
TB-500 is a synthetic, acetylated heptapeptide corresponding to the active region (residues 17–23) of thymosin β-4 — a 43-amino-acid actin-sequestering protein widely distributed in mammalian tissues.
Research interest centers on actin regulation, cellular migration, and tissue repair models. The fragment has been investigated for activity in cardiac, dermal, and corneal repair systems, and as a tool compound for studying angiogenesis and inflammation.
Each lot is independently verified for both purity (HPLC + ESI-MS) and endotoxin (LAL kinetic chromogenic) before listing.
Identity & Specifications
Sequence
Ac-LKKTETQ-OH
Length
7 residues (acetylated)
Formula
C₃₈H₆₈N₁₀O₁₃
Mol. weight
888.99 g/mol
CAS
77591-33-4
PubChem
11790547
Purity (HPLC)
≥ 98.6%
Endotoxin (LAL)
0.22 EU/mg
Reconstitution
Bacteriostatic water
Storage
−20°C, sealed
Certificate of Analysis · Lot CB26-04-002
| Parameter | Method | Spec | Result |
|---|---|---|---|
| Identity | ESI-MS | Conforms | Pass |
| Purity | HPLC-UV 220 nm | ≥ 98.0% | 98.6% |
| Endotoxin | LAL kinetic | < 0.5 EU/mg | 0.22 EU/mg |
| Bioburden | Microbial count | < 100 CFU/g | < 10 CFU/g |
| Water content | Karl Fischer | ≤ 6.0% | 4.20% |
| Appearance | Visual | White lyophilized cake | Conforms |
Selected References
- Smart N, Riley PR, et al. De novo cardiomyocytes from within the activated adult heart after injury. Nature, 2011.
- Philp D, Kleinman HK. Animal studies with thymosin beta-4. Ann NY Acad Sci, 2010.
- Goldstein AL, Hannappel E, Kleinman HK. Thymosin beta-4: actin-sequestering protein moonlighting. Trends Mol Med, 2005.
- Crockford D, et al. Thymosin beta-4: structure, function, and biological properties. Ann NY Acad Sci, 2010.
- Goldstein AL. Thymosin alpha-1 and thymosin beta-4: an update. Vitamins & Hormones, 2007.
Recent Research Highlights
2010
Dermal Wound Healing
Philp & Kleinman · Ann NY Acad Sci
Reviewed thymosin β-4 and active fragments in connection with wound closure and angiogenesis.
2008
Cellular Migration Studies
Goldstein et al.
Examined the role of thymosin β-4 fragments in actin polymerization dynamics in fibroblast models.
1991
Original Thymosin Characterization
Low & Goldstein · Methods Enzymol
Foundational work characterizing thymosin polypeptides and their biochemical properties.
⊕
3rd Party Tested
Independent lab
≥98%
HPLC Purity
+ ESI-MS
LAL
Endotoxin
LAL kinetic
§
Lot-traceable
In COA library
§ Research-Use Compliance
This compound is supplied by Crescent Bioresearch LLC for laboratory research and pre-clinical use only. It is not a drug, dietary supplement, food, or cosmetic, and has not been approved by the U.S. Food and Drug Administration for human or veterinary administration, diagnosis, treatment, or prevention of any condition.
The pharmacological, toxicological, and stability properties of this compound have not been fully studied. It must therefore be handled only by personnel trained in laboratory safety practices.
The purchaser bears sole responsibility for ensuring that all handling, storage, and intended use comply with applicable local, state, and federal regulations. Full terms are set out in the RUO Disclaimer and Terms of Service.
