2015
Skin Cell Gene Expression
Pickart et al. · Biomed Res Int
Examined effects of GHK on gene expression in fibroblasts and keratinocytes; reported broad transcriptomic shifts.
Editor's Pick
Lot CB26-04-003MFG 04/2026
About GHK-Cu
GHK-Cu is the copper-bound form of the tripeptide glycyl-L-histidyl-L-lysine (GHK), a small endogenous peptide identified as a circulating factor whose plasma concentration declines with age.
Research interest spans connective-tissue remodeling, antioxidant gene expression modulation, and stem-cell signaling. The peptide has been studied as a tool compound in dermal fibroblast cultures, hair-follicle research, and in-vitro wound-healing models.
Each lot is independently verified for purity (HPLC + ESI-MS) and endotoxin (LAL kinetic chromogenic) before listing.
Identity & Specifications
Sequence
GHK · Cu²⁺
Length
3 residues + Cu²⁺
Formula
C₁₄H₂₃N₆O₄Cu
Mol. weight
402.93 g/mol
CAS
49557-75-7
PubChem
124886
Purity (HPLC)
≥ 99.0%
Endotoxin (LAL)
0.14 EU/mg
Reconstitution
Sterile saline 0.9% or bacteriostatic water
Storage
−20°C, sealed
Certificate of Analysis · Lot CB26-04-003
| Parameter | Method | Spec | Result |
|---|---|---|---|
| Identity | ESI-MS | Conforms | Pass |
| Purity | HPLC-UV 220 nm | ≥ 98.0% | 99.0% |
| Endotoxin | LAL kinetic | < 0.5 EU/mg | 0.14 EU/mg |
| Bioburden | Microbial count | < 100 CFU/g | < 10 CFU/g |
| Water content | Karl Fischer | ≤ 6.0% | 3.45% |
| Appearance | Visual | White lyophilized cake | Conforms |
Selected References
- Pickart L, Thaler MM. Tripeptide in human serum which prolongs survival of normal liver cells. Nature New Biol, 1973.
- Pickart L, Vasquez-Soltero JM, Margolina A. GHK peptide as a natural modulator of multiple cellular pathways. Biomed Res Int, 2015.
- Pickart L. The human tri-peptide GHK and tissue remodeling. J Biomater Sci Polym Ed, 2008.
- Choi HR, et al. Skin-firming and rejuvenating effects of tripeptide-copper. J Cosmet Dermatol, 2009.
- Pickart L, Margolina A. Regenerative and protective actions of GHK-Cu peptide. Int J Mol Sci, 2018.
Recent Research Highlights
2012
Wound Repair in Animal Models
Pickart & Margolina
Reviewed historical animal-model data on GHK-Cu in dermal repair.
2009
Hair Follicle Research
Pyo et al. · Ann Dermatol
Investigated tripeptide-copper complexes in models of hair follicle activity.
1988
Original GHK Identification
Pickart & Thaler · Nature
The originating work isolating GHK as a growth-modulating peptide from human plasma.
⊕
3rd Party Tested
Independent lab
≥98%
HPLC Purity
+ ESI-MS
LAL
Endotoxin
LAL kinetic
§
Lot-traceable
In COA library
§ Research-Use Compliance
This compound is supplied by Crescent Bioresearch LLC for laboratory research and pre-clinical use only. It is not a drug, dietary supplement, food, or cosmetic, and has not been approved by the U.S. Food and Drug Administration for human or veterinary administration, diagnosis, treatment, or prevention of any condition.
The pharmacological, toxicological, and stability properties of this compound have not been fully studied. It must therefore be handled only by personnel trained in laboratory safety practices.
The purchaser bears sole responsibility for ensuring that all handling, storage, and intended use comply with applicable local, state, and federal regulations. Full terms are set out in the RUO Disclaimer and Terms of Service.
