2017
Reproductive Axis Research
Skorupskaite et al. · Hum Reprod Update
Reviewed kisspeptin signaling in human reproductive biology.
Lot CBR-KIS-260411-001✓ Verified
About Kisspeptin-10
Kisspeptin-10 is the C-terminal decapeptide of kisspeptin-54, the cleavage product of the KISS1 gene. The decapeptide retains binding to the kisspeptin receptor (KISS1R / GPR54) and has been the most-studied form in HPG-axis research.
Research interest centers on hypothalamic GnRH regulation, puberty onset, and reproductive endocrinology. The peptide is widely used as a tool compound in receptor-binding assays and in-vivo neuroendocrine models.
Each lot is independently verified for purity (HPLC + ESI-MS) and endotoxin (LAL kinetic chromogenic) before listing.
Identity & Specifications
Sequence
YNWNSFGLRF-NH₂
Length
10 residues
Formula
C₆₃H₈₃N₁₇O₁₄
Mol. weight
1302.47 g/mol
CAS
374675-21-5
PubChem
16131614
Purity (HPLC)
99.7%
Endotoxin (USP <85>)
16.5 EU/vial · PASS
Certificate of Analysis
Lot CBR-KIS-260411-001 — purity, potency, and bacterial endotoxin independently verified by BTLabs (West Palm Beach, FL).
| Parameter | Method | Spec | Result |
|---|---|---|---|
| Identity | FTIR (USP <197A>) | Confirms Kisspeptin | Conforms |
| Appearance | Visual (USP <630>) | White powder | White powder |
| Purity | HPLC-UV 280 nm (USP <621>) | ≥ 98.0% | 99.7% |
| Potency | HPLC-UV 280 nm (USP <621>) | 90 – 110% of 10 mg | 10.1 mg (101.5%) |
| Bacterial Endotoxin | Gel-clot (USP <85>) | < 40 EU/vial | 16.5 EU/vial · PASS |
Signed Certificate of Analysis
Independent third-party laboratory: BTLabs · 5730 Corporate Way, Suite 220, West Palm Beach, FL 33407 · (561) 625-0133. Three signed pages reproduced below verbatim. Open the original PDF →
Selected References
- Kotani M, et al. The metastasis suppressor gene KISS-1 encodes kisspeptins. J Biol Chem, 2001.
- de Roux N, et al. Hypogonadotropic hypogonadism due to loss of function of GPR54. PNAS, 2003.
- Skorupskaite K, George JT, Anderson RA. The kisspeptin-GnRH pathway. Hum Reprod Update, 2014.
- Lehman MN, et al. Minireview: kisspeptin/neurokinin B/dynorphin neurons. Endocrinology, 2010.
- Roa J, Aguilar E, et al. New frontiers in kisspeptin / GPR54 physiology. Front Neuroendocrinol, 2008.
Recent Research Highlights
2012
GnRH Pulse Generation
Lehman et al.
Examined kisspeptin neurons in coordinating gonadotropin release.
2005
Puberty Onset
de Roux et al. · PNAS
Established the role of GPR54 / kisspeptin in pubertal initiation.
2003
KISS1R Identification
Kotani et al. · J Biol Chem
Characterized the kisspeptin receptor and ligand binding properties.
⊕
3rd Party Tested
Independent lab
≥98%
HPLC Purity
+ ESI-MS
LAL
Endotoxin
LAL kinetic
§
Lot-traceable
In COA library
§ Research-Use Compliance
Laboratory research chemical / reagent — not a supplement or drug.
This compound is supplied by Crescent Bioresearch LLC for laboratory research and pre-clinical use only. It is not a drug, dietary supplement, food, or cosmetic, and has not been approved by the U.S. Food and Drug Administration for human or veterinary administration, diagnosis, treatment, or prevention of any condition.
The pharmacological, toxicological, and stability properties of this compound have not been fully studied. It must therefore be handled only by personnel trained in laboratory safety practices.
The purchaser bears sole responsibility for ensuring that all handling, storage, and intended use comply with applicable local, state, and federal regulations. Full terms are set out in the RUO Disclaimer and Terms of Service.
