2015
Original Identification
Lee et al. · Cell Metab
Identified MOTS-c as a mitochondrial-derived peptide and characterized its metabolic role.
Lot CBR-MOT-260403-001✓ Verified
About MOTS-c
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA, identified in 2015 as one of the first known mitochondrial-derived peptides (MDPs). It is implicated as a regulator of metabolic homeostasis and mitochondrial-to-nuclear retrograde signaling.
Research interest centers on AMPK-pathway signaling, insulin-sensitivity studies, and mitochondrial-encoded signaling biology. The peptide is among the most-studied mitochondrial-derived peptides in metabolic research.
Each lot is independently verified for purity (HPLC + FTIR) and endotoxin (LAL, USP <85>) before listing.
Identity & Specifications
Sequence
MRWQEMGYIFYPRKLR
Length
16 residues
Formula
C₁₀₁H₁₅₂N₂₈O₂₂S₂
Mol. weight
2174.59 g/mol
CAS
1627580-64-6
PubChem
146675088
Purity (HPLC)
99.8%
Endotoxin (USP <85>)
36.6 EU/vial · PASS
Certificate of Analysis
Lot CBR-MOT-260403-001 — purity, potency, and bacterial endotoxin independently verified by BTLabs (West Palm Beach, FL).
| Parameter | Method | Spec | Result |
|---|---|---|---|
| Identity | FTIR (USP <197A>) | Confirms peptide | Conforms |
| Appearance | Visual (USP <630>) | White powder | White powder |
| Purity | HPLC-UV 280 nm (USP <621>) | ≥ 98.0% | 99.8% |
| Potency | HPLC-UV 280 nm (USP <621>) | 90 – 110% of 40 mg | 50.1 mg (125.2%)† |
| Bacterial Endotoxin | Gel-clot (USP <85>) | < 40 EU/vial | 36.6 EU/vial · PASS |
† Measured fill exceeds the labeled potency — the active content is above the 40 mg label, not below. The lab confirmed identity and purity; the overfill is documented on the signed certificate.
Download signed certificate →Download Safety Data Sheet →Selected References
- Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. Cell Metab, 2015.
- Kim KH, et al. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus. Cell Metab, 2018.
- Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator. Nat Commun, 2021.
- Yen K, et al. The emerging role of mitochondrial-derived peptides. Trends Endocrinol Metab, 2020.
- Cobb LJ, et al. Naturally occurring mitochondrial-derived peptides. Aging, 2016.
Recent Research Highlights
2018
AMPK Activation
Kim et al.
Examined MOTS-c effects on AMPK signaling in skeletal muscle research.
2019
Insulin Sensitivity
Various
Multiple groups have investigated MOTS-c effects on glucose uptake and insulin signaling.
2020
Aging Research Models
Reynolds et al.
Examined circulating MOTS-c levels and mitochondrial-encoded peptide biology in aging research.
Signed Certificate of Analysis
Independent third-party laboratory: BTLabs · 5601 Corporate Way, Suite 206, West Palm Beach, FL 33407 · (561) 625-0133. Three signed pages reproduced below verbatim. Open the original PDF →
⊕
3rd Party Tested
Independent lab
≥98%
HPLC Purity
+ FTIR
LAL
Endotoxin
LAL · USP <85>
§
Lot-traceable
In COA library
§ Research-Use Compliance
Laboratory research chemical / reagent — not a supplement or drug.
This compound is supplied by Crescent Bioresearch LLC for in-vitro laboratory/experimental research use only. It is not a drug, dietary supplement, food, or cosmetic, and has not been approved by the U.S. Food and Drug Administration for human or veterinary administration, diagnosis, treatment, or prevention of any condition.
The pharmacological, toxicological, and stability properties of this compound have not been fully studied. It must therefore be handled only by personnel trained in laboratory safety practices.
The purchaser bears sole responsibility for ensuring that all handling, storage, and intended use comply with applicable local, state, and federal regulations. Full terms are set out in the RUO Disclaimer and Terms of Service.
