2010
BDNF Expression
Dolotov et al.
Examined Semax effects on BDNF and TrkB receptor expression in rodent brain.
Lot CBR-SMX-260403-001✓ Verified
About Semax
Semax is a synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH 4-7) with a Pro-Gly-Pro C-terminal extension for proteolytic stability. The peptide was developed at the Russian Institute of Molecular Genetics.
Research interest centers on neuroprotection, BDNF expression, and pre-clinical cognition paradigms. Semax has accumulated a substantial Russian-language research literature with translated reviews available.
Each lot is independently verified for purity (HPLC + FTIR) and endotoxin (LAL, USP <85>) before listing.
Identity & Specifications
Sequence
MEHFPGP
Length
7 residues
Formula
C₃₇H₅₁N₉O₁₀S
Mol. weight
813.92 g/mol
CAS
80714-61-0
PubChem
9811102
Purity (HPLC)
99.6%
Endotoxin (USP <85>)
15.5 EU/vial · PASS
Certificate of Analysis
Lot CBR-SMX-260403-001 — purity, potency, and bacterial endotoxin independently verified by BTLabs (West Palm Beach, FL).
| Parameter | Method | Spec | Result |
|---|---|---|---|
| Identity | FTIR (USP <197A>) | Confirms peptide | Conforms |
| Appearance | Visual (USP <630>) | White powder | White powder |
| Purity | HPLC-UV 220 nm (USP <621>) | ≥ 98.0% | 99.6% |
| Potency | HPLC-UV 220 nm (USP <621>) | 90 – 110% of 10 mg | 10.2 mg (101.7%) |
| Bacterial Endotoxin | Gel-clot (USP <85>) | < 40 EU/vial | 15.5 EU/vial · PASS |
Selected References
- Ashmarin IP, et al. Semax and other ACTH-derived neurotropic peptides. Neurochem Res, 1997.
- Dolotov OV, et al. Effects of Semax on BDNF expression. Neurosci Lett, 2006.
- Gusev EI, Skvortsova VI. Brain ischemia. Springer, 2003.
- Kaplan AY, et al. Effects of Semax on attention and memory. Eksp Klin Farmakol, 1996.
- Vyunova TV, et al. Peptide neuroprotection. Curr Drug Deliv, 2019.
Recent Research Highlights
2008
Cerebral Ischemia Models
Gusev et al.
Investigated neuroprotective effects in pre-clinical stroke models.
2003
Cognition Research
Kaplan et al.
Evaluated Semax effects on learning and attention paradigms.
—
ACTH-Derivative Family
Various
Part of a larger family of ACTH-derived peptides studied in neuromodulation research.
Signed Certificate of Analysis
Independent third-party laboratory: BTLabs · 5601 Corporate Way, Suite 206, West Palm Beach, FL 33407 · (561) 625-0133. Three signed pages reproduced below verbatim. Open the original PDF →
⊕
3rd Party Tested
Independent lab
≥98%
HPLC Purity
+ FTIR
LAL
Endotoxin
LAL · USP <85>
§
Lot-traceable
In COA library
§ Research-Use Compliance
Laboratory research chemical / reagent — not a supplement or drug.
This compound is supplied by Crescent Bioresearch LLC for in-vitro laboratory/experimental research use only. It is not a drug, dietary supplement, food, or cosmetic, and has not been approved by the U.S. Food and Drug Administration for human or veterinary administration, diagnosis, treatment, or prevention of any condition.
The pharmacological, toxicological, and stability properties of this compound have not been fully studied. It must therefore be handled only by personnel trained in laboratory safety practices.
The purchaser bears sole responsibility for ensuring that all handling, storage, and intended use comply with applicable local, state, and federal regulations. Full terms are set out in the RUO Disclaimer and Terms of Service.
